Canine Melanoma (Mostly Non-Oral)
June 24, 2001
On June 18th, 2001, I got the biopsy results back that Leilah the Wonderpuppy had a "Benign Melanoma". I have also found that this can be especially tricky to pigeonhole as benign or malignant, and that in our case, benign is not a firm diagnosis. We are not home free just yet.
There is an amazing amount of info out there online to sort through, much of it is not helpful since it pertains mostly to oral melanoma or blurbs about experimental gene therapy. If Oral Melanoma is the diagnosis on your dog, you can find lots of info by searching using the words "Canine Oral Melanoma". Leilah had it on her anus, not in her mouth, and location is apparently very important for the prognosis. While oral melanoma info may have descriptions of the progression of malignancy, I haven't checked that out yet. While I have found almost no info on anal melanoma so far, but I have found some good reading. I was warned at my vet's office to be careful about finding info on canines, not humans.
So, even though it's only been a few days since I got the biopsy results, I want to start this page and share the links and info I found helpful, as well as organize this info for myself (my "class notes" so to speak). Plus doing this is better than sitting and worrying, and not keeping busy building a webpage! If you know me, then you know I build webpages at the drop of a hat and am a serious linkaholic. This is going to be a work in progress for quite a while, I think, maybe changing from day to day for now at least.
Or, keep reading for the blow by blow....
She's been to many public places, trials and matches, charity dog walks, and dog parks, and has been around hundreds of dogs, and except for a kennel cough running rampant around the neighborhood a few years ago (one not there was a vaccine for), she has never so much as a runny nose or drippy eye. I've believed her immune system to be overall pretty strong (and if it wasn't, this cancer could be worse maybe?). Her titers (tests that measure immune response to certain diseases, I get them done in the years I don't vaccinate) have always come back good. I do know Leilah's mother, a purebred Vizsla, had uterine and skin tumors. I also assumed that they were probably hereditary. The uterine tumors were extra reason for me to spay Leilah before her first heat. But, I've always tried to make sure that I keep close watch for anything suspicious on Leilah because of her mother's history.
After about a week and a half, I noticed a darkish spot to the right of the anal opening, not a lump, more like an irritation. Enough is enough, so off to the vet. While it turns out that the licking and second spot (it was an irritation) was because of full anal glands, he was suspicious about the lump, and did a needle biopsy right then and there. I do appreciate the coincidence that led me to find this lump, it is the only time in Leilah's life she's ever needed help with the anal glands, and it was not related to the lump.
The needle biopsy was a very very small sample, the pathologist was not able to see any cancer cells and could not identify it, probably because it was so small. My vet thought it was probably hemangioma, a benign tumor of the blood vessels. Since it had not increased in size at all, my vet wanted to wait another week or two before removing it on the chance that breaking it with the biopsy needle might get it to shrivel and reduce a bit.
On June 14, the tumor was removed. My vet let me be present for the entire surgery and recovery, it was wonderful for my psyche to be there. He removed the tumor plus a good margin of skin around it, and sent it off to the pathologist for identification.
This first pathology report
on the tumor said:
2) Two Tissue(s) less than 1 cm. All tissue processed. Additional upper margin of tissue near the mass?
Ok, cool, it's small! But, small enough? Hmmm, gotta start looking up words here (like what's pedunuclated?). And, yes, the additional sample was the upper margin, I was there when the vet removed it. Gotta realize that the pathologist was not there and hasn't seen the whole dog, he's only looking at her cells in a microscope.
So far so good!!! It went on to say....
These benign tumors are common in dogs, especially heavily pigmented breeds. They are found anywhere on the body, but are unexpectedly common in sites such as haired skin of the eyelids or lips that are not commonly affected by other benign neoplasms. These tumors are benign and in some dogs, histologically benign melanomas may develop in multiple intraepidermal sites.
Ok..... that's all well and good I think, but then....
However, if this neoplasm was at the mucocutaneous junction, this tumor could be considered malignant. It has been reported that melanomas of mucocutaneous junction are invariably malignant.
Huh?? It's benign but maybe not, based on where it is? And, is the anus considered a "mucocutaneous junction"? "Invariably malignant" sounds REAL scary.
Well, I know that's good news!
My vet had talked to the pathologist and the oncologist at the lab before he even called me and left a message on my answering machine. They had told him it had a low mitotic rate (rate of cell division), was not aggressive. Talking to him the next day after I had looked up a few definitions and other things, it seems the pathologist thought the sample was from haired skin, but I know there was no hair where the tumor was. It was not "staged" (stage 0 through 4, 4 being worst) because it is considered benign. All this actually left me with more questions, like exactly what kind of skin is involved here, is this on the mucocutaneous junction or not, is this really benign or not, and now what?
Pinning it down
My vet was wondering about this too, were there hair follicles definitely in the sample or something? So, we asked the sample to be re-evaluated again. Preliminary results of that show that the borders are quite clean, she could not find any dividing cells, which is what is measured as "mitotic rate". (Turns out that benign melanoma is considered to have a mitotic rate of under 2, so this is great news!). Bad news is that this apparently is on the mucocutaneous junction. We think the haired follicles were from the wide margins the vet removed, but can't get a confirmation on this either way. The addendum from the re-evaluation does go on to say that there is a "concern for malignancy" because of the location.
So, we have mixed results, some criteria (mitotic rate, encapsulation, clean margins) saying it's benign, at least one saying it's "invariably malignant" (the location of where it was). Nothing real concrete, grrrrr.
Healing from the surgery
She is not on any restricted activity, it's not like when she was spayed and not allowed to run and jump, movement will not bother these sutures. The vet told me that if I take her around other dogs, the usual butt sniffing should not be a problem. Until at least the sutures are out, we have stopped all training, we needed a training break anyway. Plus I think it's just plain rude to ask her to sit on the sutures, even though she can with apparently no problem. But I'm not gonna ASK her for it. She can go without the collar if carefully supervised (she has a good "leave it" command") so I still took her to the dog park the second weekend after the surgery and she had a great time. She also gets supervised time without the collar every evening, so she can eat in her accustomed "roman dog" style - laying down. But if she wants to eat with the collar, she just has to stand up. At first she only wore the collar when I was asleep and when not home, I thought I could supervise her enough, but by the third day the suture area was a bit swollen and it looked like she may have been sneaking at them to lick them. So, the collar became almost full time and the next day the sutures were looking much better.
Recovery at this anal surgery location was not the problem it may seem to be. I don't have to follow her around with disinfectant when she poops. The vet used silk sutures so they're as soft as possible and less chance of bothering her than other types, and she's got 6 stitches. She got a short course of antibiotics for a week. I needed to check the sutures at least or twice once a day, but I do check them much more often, especially after she poops. For the first couple of days, it bothered for her to squat, but that improved quickly.
I do need to clean any fecal material with a paper towel and water if there is any. It's pretty tender to do that, so I kind of blot it gently and checked the towel for brown marks, until there's no more marks. She cooperates with this though she does not like it. She is already well trained and gets high octane goodies for her cooperation. There has been very little catching of fecal material on the cut ends of the sutures, but that's what seems to happen if anything at all. I've only had to do clean them twice so far in a bit over a week. It's harder to tell than you would think, looking for dark fecal material on dark stitches on a dark butt, you need good light. I suggest if you have an obedience trial dog, that you do NOT used the stand command much, since it can create a negative association with the command and could cause training problems later. The "command" I've used here is to touch her abdomen at the tuck up and I often need to keep my hand or arm there to prevent her from sitting down. For cleaning, I have my arm reaching under her and that hand holding up tail while other hand works with paper towel. She's not a big dog. The antibiotics did not give her diarrhea thank goodness.
As I have been telling my friends, the moral of this story is to check your dogs for any lumps and bumps, and have them looked at. Lift those tails, take a good look, and tell them you love them!
July 3, 2001
We went to the oncologist on Thursday (today's tuesday). Here's what I posted on a friend's message board on June 28:
In the meantime, we're not sitting around. Leilah is scheduled for an ultrasound check up of her lymph nodes next Thursday, as well as a urinalysis from a sterile sample. This is not pie plate time, they'll go in and get it with a needle. That makes me cringe thinking about it. I'm gonna ask about why not use a catheter. They gonna shave her funny for the ultrasound, and as slow as her hair grows back (took many many months, most of a year, for spay shave to disappear), I'm guess I'm gonna have to convince her she's just trendy and ahead of the pack LOL. I need to find out if she'll need sun protection for a while and maybe make her a light weight shirt. Sunscreen is out of the question, she likes the taste way too much, it's all I can do to make her leave it on me.
If they cannot resolve after all this that it really is benign, the onco is talking about immune system boosting drugs and chemotherapy, possibly even if we don't have firm confirmation that's it's metastasized. She has also referred me to a holistic vet for nutritional and supportive information. He's well known around here, I know lots of his patients, wish us luck we'll even get in.
Leilah is to no longer get ANY vaccines, ever, including rabies. She says they will get me a waiver for that so city of LA will still give me the dog license. She got the rabies in early december and her 4 way a bit later, so I have a long while before I have to deal with that anyway - she'll be 7 (she's 4 now). Just I am worried about the ramifications after that if she ever had even an accidental bite claim against her, there is no titer for rabies yet.
Of course I will research like hell and try my best to make the most informed decisions I can. My vet apparently did an excellent job with the surgery, got good borders, even if it is eventually malignant he apparently bought us the time to do these diagnostics before committing to anything. Even though the 6 sutures were only removed about 5 hours earlier, the oncologist could not see where they had been, it's healed so well! The xrays my regular vet took this morning show everything is great, no swollen lymph nodes pushing on anything, lungs nice and clear. Onco felt out lymph nodes that she could feel and did rectal check, everything ok there too.
In the meantime, we are all
thrilled with the banishment of the elizabethan collar, and Leilah is snoozing
in my lap as usual. It's tearing me up what this is doing to my beautiful
sweet girl, I really REALLY hated it that she even had to tolerate removing
the tumor and the e collar, let alone the rest of this! I think I hated
it more than her. I want her life to always be sunshine and roses, laps
and nylabones. But, we know that some rain must fall, and hopefully
it will only be a little for her.
Well, I have since done a bit of research on the drugs that the oncologist thinks we may use. Carboplatin is a drug that is apparently recommended for human ovarian cancer. I have found some references to it being used for canine melanoma, but haven't been able to see the studies yet. The big problem with this treatment is it suppressed bone marrow, leaving Leilah at higher risk of passing infections. While the oncologist says it's not as severe in dogs and goes to quality of life issues, so I don't have to really isolate her. But, when I first lost my husband, we went many months without going out at all, she's been semi isolated for long periods before and didn't seem to have a problem with it. My paranoia would keep her out of trials and dog park anyway, the biggest sources of infection she's exposed to. She would still have my other dog and my trainer's dog to play with, as well as me, all on private property where these dogs are the only ones ever there. I still have a LOT more research to do on all this.
Piroxicam is an NSAID (Non steroidal anti inflammatory drug) that apparently boosts interleuken 2 production - kind of a natural immuno/chemotherapy. Of course that runs the GI tract risks that comes with all NSAIDs. I've learned that often antacids are giving with this drug (which is always given with food) and need to find out if Tagamet will fill this bill. The oncologist said there is one anecdotal incident of a horse with melanoma improving with Tagamet. Of course since I've learned some cancers can go into remission on their own, this doesn't necessarily mean a whole lot, but if it's appropriate I might as well use it.
We see the holistic vet on July 19th. He has an excellent reputation, I've known many of his clients. I am hoping I can leave Leilah on her current kibble, Canidae, it's agreed with her quite well and is highly rated for being "natural" and high quality for a processed food. I can hardly prepare food for myself at all, I live out of fast food places and the microwave oven. I've honestly made exactly one full meal from scratch in my life, that was in 1983 and was a disaster. So preparing home made meals for Leilah will be difficult for me. But, if it's gonna be critical, I'll manage! We'll see. Hopefully I can use just supplements to boost her immune system and help with chemo if she gets it.
Tomorrow's 4th of July, my
best friend is bringing some reference materials for me when she comes
over, info on how to interpret blood tests, etc. She is currently
a nursing teacher (has her masters), but also has her undergrad degree
in animal science and was a licensed animal health technician for many
years before she went into human nursing. We're gonna go to the local parade
with her kids and my Leilah, and I'm gonna try to pretend nothing
could be wrong. Leilah loves going, she gets so much attention and
is convinced when people clap that the applause is for her!
Ok, here is my list of questions/notes for oncologist. This is in addition to the list of questions on the Canine in Crisis site, and is more specific to Leilah's case. I've put in the answers as I remember them. I didn't manage to ask all of them even though she gave me plenty of opportunity and I had them written down, but I was pretty nervous. I skipped most of the questions about further treatment and progression since we don't know yet if anything will ever be required. These are NOT her quotes, I'm paraphrasing here for the most part.
1. Is this pathology report
2. Don't we need to know:
3. Do we need 2nd pathologist
4. Do we need cytologist
5. Does this even need to
6. Other diagnostics for
7. Is this considered “well
8. Does that make it harder
or easier for her to fight it?
9. Have you ever seen anal
melanoma? Smooth skin melanoma?
10. Can you find any info
on anal melanoma in dogs? What does it say? May I see?
11. How dangerous is this,
being on the mucocutaneous junction.
13. Has it spread?
14. Where did it spread to?
20. What further testing
can be done to confirm malignancy?
22. Blood tests? Ki67 Tumor
27. How often does she need
to be rechecked assuming she's ok now?
28. Does metastasis
have to be confirmed or are there things we should do now to prevent it?
29. What should I watch
31. Recommended reading?
33. Treatments – what
34. why that kind?
35. How long will it hurt
THE BIG QUESTION: WILL SHE
Whew! she's pretty patient,
July 6. 2001
Leilah got the ultrasound and urinalysis yesterday. Results of both were good WHEW!!!!! Everything they looked at was normal, so if this thing is spreading, it's not spread far at all yet. We are still waiting on the results of the second pathologist's report, the samples arrived at his office today. That's the BIGGIE. But, with these ultrasound results, I'm considering breathing again!
The ultrasound shave wasn't as severe as I thought, it's like a spay shave gone bonkers. I do have to protect her from sunburn on her belly and sides until her hair grows back enough to protect her. The UV index here is maxed out at 10 for most of the summer and her fur grows back very very slowly. It took most of a year for her spay shave to grow back. And, she loves to lay out in the sun before I wake up ( I work nights so I sleep until late morning). So she can still head out the dog door before I get up and be the "sundog", I will first try sunscreen on her. Problem with that is she likes the taste of many sunscreens, she barely lets me wear them sometimes! Hopefully I can find one that is safe, will stay on and lasts long enough. The oncologist recommended Bullfrog because it's waterproof. Problem is that it is a bit greasy and Leilah does sleep in my bed. But, I'm gonna try it. If it doesn't work for us, I got some cheap tshirts I can modify, and found an extra large (great dane size! Leilah's only 33 lbs) dog tshirt that does cover her whole back. With a little elastic belt around her waist and a tail loop, that might work. It's a Harley Davison shirt too, "Hog Dog" and my husband would be so proud! On the 4th of July, my friend brought over some shirts her kids outgrew. Locking her inside in the mornings will be a last resort.
I've been doing a lot more reading, including some basic holistic stuff. I sure hope the holistic vet makes more sense than that little book I got, some of this just doesn't make sense. Found out that there are places that will do rabies titers too, but don't need that for a long time anyway. Still looking up more stuff about the drugs too and finally invested in a new medical dictionary (one I had been using was from 1962!). My friend is loaning me a copy of Mosby's Manual of Diagnostic and Laboratory tests. That's for humans, so the values aren't applicable, but the generalizations pretty much apply.
Now, all we gotta do is wait a few more days for the pathologist's report. The oncologist said that if he finds no muciod tissue, we might be home free with this one! But, if it's bad news, I hope I have a start on the info I need to handle it. Prepare for the worst and hope for the best.
July 7, 2001
I got the BEST wakeup call from the oncologist this morning. The results came in from the dermatopathologist. LEILAH'S OK and she's recommending NO further treatment! We will need a followup visit in 3 months. I haven't seen the pathology report yet, but there's no muciod tissue involved, everything looks good. That was the big worry. I've been practically shouting it from the roof tops!
Leilah will not be undergoing any chemo or other procedures, assuming she gets no more tumors. But, for this melanoma tumor, and this page, this is the happy ending! Of course that means I will not have much more to add to this page, but I will finish adding the links I've collected and organize them a bit more, and maybe info from the report when I get it.
In the meantime, we're gonna go out an PLAY!
The final diagnosis from the dermatopathologist is "benign compound Melanocytoma". I'll include some links on it below. Compound means that more than one skin layer was involved, both the epidermis and dermis. Vizslas are at higher risk for it than other breeds, and she is half Vizsla. Melanocytoma is a benign tumor, basically a type of mole and they may be precancerous. It may be that Leilah cannot be considered to have had cancer at all, so I don't know if the oncologist still wants to give us a rabies waiver, we'll see. I'm not gonna sweat it for now anyway.
In the meantime, Leilah's only remaining "treatment" is the application of Bullfrog sunscreen, spf 45, 2x day. Surprisingly, we've made that work though I sure doubted it at first. Just where she was shaved for the ultrasound, until her hair grows back. She sure doesn't mind THAT at all, it's all just a belly rub for her. I got advice from a sun sensitive friend that the first half hour after putting on a sunscreen is the most important for it's effectiveness (Thanks Jo-anne!), and hopefully I can prevent her from licking for at least that first half hour. Not that hard actually, I rub it in with one hand for 15 - 30 mins, and play a computer game with the other hand. Then I don't have long to supervise her so closely after that especially if I distract her afterwards for a little while. Her hair is starting to grow a bit thank goodness, it will be interesting to see if the color changes at all (since her colors change anyway as she matures).
I am finishing up the links and organizing them a bit, but after this I hope to not have to add to this page at all (other than link updates).
I feel like we missed a bullet,
and am so overjoyed she's ok! My regular vet, who I saw today with
my other dog, is pretty overjoyed too. He had a non stop ear to ear grin
about it! Pretty much how I've been too!
July 28, 2001
The sunscreen may have not been so good for her after all, indirectly. She developed an unspecific vaginitis. Suspects were some minor infection introduced by the sterile urine sample, or yeast infection from taking the antibiotics, or something to do with the sunscreen. She did lick the sunscreen some, even though I rubbed int in real good, and I thought maybe she'd licked it across that sensitive skin. The morning of the holisitic vet appointment (I kept that appoinement even though she won't need chemo now), I ran her to the regular vet, he said there was not even any kind of discharge to culture, but suspects some kind of bacterial infection. It was basically a "process of elimination" diagnosis, probably not from the urine sampling, nor is this acting like a yeast infection. When I saw the holisitic vet later that day, she suspected the licking at the sunscreen had maybe spread a bit of e. coli or other bacteria. She gave us acidophilus to support Leilah with the antibiotics. So, to cut down the licking, I stopped the sunscreen totally. We've had a marine layer here anyway most days and it's not been real bright out, plus she's grown some hair back to help protect her. The area is tanning though (she gets a blackish tan, not a brown one like I do), but not burning. I am planning on going to our club match with her next weekend, will be out all day, so will bring a shirt for her.
Visiting the Holisitic Vet was real interesting. Here's a post I wrote about it:
Still plenty hot, maybe mid
80s, not 90 like my mom said. But, with the cool coat,
I saw his wife actually, not him, and she's real sweet. They all fussed
over her too
when I mentioned that maybe I should toss her an occasional chicken wing
She is not sure if the Canidae is good enough for her, and it does have
She gave me acidophilus for Leilah to take with the other vet's antibiotics
Of course I gotta try to replace the bowls, the stainless steel I'm using
is not human
Just DANG, with my set up and MO, all this is going to be tough to settle
in to what
She checked Leilah's pulse and tongue and she thinks Leilah has "damp"
Another post about cooking for her:
Ok, I honestly don't cook,
really really, other than pasta and an occasionally
The vet says to try to give her at least SOME home cooking if I can. I
look at this
She gaves me a basic recipe, which I modified for my convience. Instead
Of course first, I hadda go buy it all. Got lucky, found a bagged, chopped
Get it all home, along with glass food and water bowls, and glass storage
After looking up how to do it in the cookbooks and on the 'net, I decide
to nuke the
So, first night ends with the veggies all cooked (vet said to cook them!).
Tonight, after another long day
I've thrown away a LOT of food too, had way more parsely, garlic, and spinach
HOPEFULLY, I'll get the fridge stuff figured out, then I can just add the
Found that using carrots for a training treat is too difficult to keep them fresh for when the training impulse strikes (I don't have a routine these days). So, using Charley Bears from Trader Joe's and a natural puffed corn cereal I found at the market (no sugar, no preservatives). She has no real problem with corn, I don't want it to be in her regular diet if I can help it, but I think it's ok for treats. Also natural bread sticks, though those are a bit too crumbly. Got through training yesterday with a minimum of old treats. I'm still probably gonna use the junk food when I need REAL high octane treats, or at trials (that's only about a half dozen times a year) but now that will be minimal.
For a glass water bucket I ended up putting a glass cookie jar inside the bucket I'm already using. Now they're drinking out of glass, but I still have all the convience of the bucket! I can still tie it to the closet so they don't knock it over, easier on my back to pick it up, too high for them to step in easily, etc... Filling it with a Brita Pitcher that now lives in the bathroom.
This cancer scare has put
the fear into me, I'm gonna do what I can to make it less likely to happen
again. As the vet said, that I can take this slow, and work it in over
time, after all, any of these changes is better than none.
October 7, 2001
Leilah had her first 3 month follow up with the oncologist last Thursday, all is well! We'll see her again in another 3 months.
Leilah also saw the holistic vet for a followup a few weeks ago. We saw the other vet in the practice, the husband. He changed the vitamins for her. He also started her on 1 oz Noni Juice every day. This stuff IS bucks and hard to get. I researched it, and found that guy who supposedly studied it may have had ethics problems, hadda leave a university over it, and at least one lawsuit over falsified claims of other products. So, I figure that this study is not something to consider. But, there is a lot of ancedotal evidence that it may help her immune system, including from the vet himself, he gives it to his own dogs. He has no other info to give me about any studies, I did ask. I can find no info that it will harm her or hurt in any way other than my wallet, so gonna try to keep it up for her.
I apparently have messed up the supplement recipe, but Leilah seems ok in spite of my (lack of) cooking skills. She was getting about 1/2 cup a day, not 1/4 as I thought (am measuring portions using a big serving spoon). I guess I got pounds and quarts messed up, and was thinking 32 oz in a pound! Her supplements have actually been 2/3 veggies and 1/3 meat, but I think they werre supposed to be 1/2 and 1/2. Fortunately, I figure it's only accounted for about 50% of her diet, she's still free fed Canidae kibble. I can't find the original recipe and will try to call the vet on Monday and find out more, and if I should thaw out the 6 weeks worth that I just made and add more meat, or if it's ok for now. I've been giving her these proportions the whole time, argh!
Her diet now consists of:
Morning:Tahitian Noni Juice, 2 Tablespoons with a pinch of natural puffed rice.
2 fish oil/omega acid caps, "black fish", from Merrit Naturals.
1 teaspoon vitamin powder from Merrit Naturals (only until I run out, vet said to give it concurrently with other vitamins and use it up)
1 tablespoon Nupro vitamin powder.
1/2 teaspoon Barley Dog powder.
Except for initially with the Noni juice, Leilah just scarfs all this stuff right up! Adding a small bit of rice to the Noni, which should be given on an empty stomach, helped a lot. Now she laps it up pretty quickly.She usually doesn't eat her kibble in the mornings, so that's a good time to catch her on an empty stomach. The Nupro must stick to her mouth like peanut butter, lots of licking the roof of her mouth type maneuvers since I started adding it. .
She's still at high risk,
and I'm gonna do whatever I can for her!
Facts I've learned about Canine Melanoma
First, be aware that I am NOT in the medical field. I am just a scared dog mom who's now spent many hours trying to find info on this. My focus is on non-oral canine melanoma, since my Wonderpuppy was affected on her anus.
It happens more to dark dogs than light dogs, unlike humans. It is probably not sun related in these cases (which is good, because if I tried to put sunscreen on that little butt, she'd try to lick it off - she's got a taste for sunscreen).
Bad places for it to occur is in the mouth, on the toes, or anyplace there's mucus membrane, or transition areas between skin and mucus membrane. Happens on eyelids too, but I got the impression that's not so dangerous.
Haired skin a better place to get this.
If the tumor is encapsulated (in a fibrous package and not messy with cells in surrounding skin), it's good news.
It's possible to have mixed criteria for benign vs malignant on the same tumor.
Surgery is the first line of defense and is often completely curative.
Getting mixed info whether chemo or radiation would be appropriate if more help is needed. I'm seeing more references to radiation.
Benign melanoma and melanocytoma may be the same thing. My vet says they're interchangeable terms, but I have not found much about it. The references to melanocytoma I'm finding are mostly about ocular melanocytoma, in the eye.
Schnauzers are more predisposed to Melanoma, along with Doberman Pinschers, Scottish Terriers, Irish and Gordon Setters, and Golden Retrievers. This suggests that sometimes it may be hereditary. Miniature and Standard Schnauzers, Doberman Pinschers, Golden Retrievers, Irish Setters, and Vizslas are more predisposed to melanocytoma.
In humans, prognosis for ano-rectal melanoma is poor. This may not hold for dogs.
One of the best indicators for a melanoma being benign is a mitotic rate (cell division measurement) of under 2. The next best indicator is apparently location. And, those indicators can conflict.
It looks like there is no apparently blood yet test to directly detect canine cancer or if it's spreading (like the PSA test for humans to detect prostate cancer).
While melanoma can metastisize to almost anywhere (per human info), it is dispersed via blood and lymphatic system and one of the most common progressions is into "regional" lymph nodes (local to primary tumor) first. Most common organs affected are liver and lungs are common sites. It can cross the blood-brain barrier and metastasize there too.
There may be melanoma risk in light dogs which might be sun-related. It might be a good idea to put sunscreen on the tips of their ears to help prevent burning and exposure.
Leilah's Cancer and Melanoma Links
* are links that weren't working on the last update, hopefully they'll come back.
Please note if I posted a warning about photos on some links. I am a wuss and it's possible some of you are too. Most are photos of surgery or cancers on animals. If it made me cringe, I put a warning on it.
Some of these links have
reference to research papers that could be helpful but are not online where
I have access to them. Ask your vet about how to get copies of them.
Some are "abstracts", just a short article about a study.
General Cancer Info and Helpful Links
Canine Cancer Files
Online Medical Dictionary
Abbreviations and Acronyms
in the Canine
So Your Pet Has Cancer
rules for Managing the Cancer Patient
is Cancer Diagnosed?
are the steps in a workup for pets....?
Owner's Guide - Canine Skin
Skin, Hair and Nail Anatomy in Dogs and Cats A short description of canine skin
Tracks Newsletter (skin diagram)
About Fatty Acids
Miniature Schnauzer Club - Canine Melanoma
of Ano-Rectal Junction
Microscopy - James E. Hayden - Infiltrating Melanoma in Canine Dermis
Variable Cytological Appearance of Melanoma in Dogs
Melanoma - General Information
- NCI/PDQ Patient Statement: Melanoma
- NCI/PDQ Physician Statement: Melanoma
Skin Tumors in Domestic Mammals - Canine Skin Tumors
of Mesenchymal Tumors *
Cancer Institute - Melanoma Treatment
Control Journal - Melanoma Metastasis
Institutes of Health - Diagnosis and Treatment of Early Melanoma
Animal Oncology Into the New Millennium
Retriever Health Manual
Carboplatin, Piroxicam, and other chemotherapy
Squibb - Paraplatin
Elizabeth Fox, DVM, MS
Foundation - Common Cancers
Merck Veterinary Manual
The Merck Manual is now online at: http://www.merckvetmanual.com/mvm/index.jsp though I don't know if all of it is there.
Dog Owners Home Veterinary Handbook - Carlson and Griffin
Davis Book of Dogs - Edited by Mordecai Seigal
and Haircoat Problems in Dogs - Lowell Ackerman, DVM
Manual of Diagnostic and Laboratory Tests - Kathleen D. and Timothy
Pill Book Guide to Medication for Your Dog and Cat
Essential Guide to Natural Pet Care for Cats and Dogs - Cancer - Cal
Cancer Studies and Research